| *蛋白激酶受体B6抗体是我司为您提供的高品质抗体，公司生产的每一个抗体都经过严格检测和稳定性测试，保证了结果的准确性、敏感性、特异性。公司产品质量有保证，*，为广大客户提供完善的售前、售中、售后服务，公司生产的产品也已获得广大客户的信赖。南京森贝伽生物科技有限公司为服务更多科研工作者的需要，公司现经营抗体、ELISA试剂盒、标准品、染色液、染色试剂盒、培养基等多种科研产品，如有需要可与我司销售人员。
英文名称 EphB6
中文名称 *蛋白激酶受体B6抗体
别 名 EPH receptor B6; EphB6; EPHB6_HUMAN; Ephrin type B receptor 6 precursor; Ephrin type-B receptor 6; HEP; MGC129910; MGC129911; Tyrosine protein kinase defective receptor EPH 6; Tyrosine-protein kinase-defective receptor EPH-6.
说 明 书 0.1ml 0.2ml
研究领域 免疫学 发育生物学 神经生物学 信号转导 生长因子和激素 激酶和磷酸酶 细胞类型标志物
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 111kDa
细胞定位 细胞膜 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EphB6
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
*蛋白激酶受体B6抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
*蛋白激酶受体B6抗体产品介绍 background:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. [provided by RefSeq, Jul 2008].
Function:
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Subunit:
Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.
Subcellular Location:
Membrane; Single-pass type I membrane protein. Isoform 3: Secreted.
Tissue Specificity:
Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
Post-translational modifications:
Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 1 Eph LBD (Eph ligand-binding) domain.
Contains 2 fibronectin type-III domains.
Gene ID:
2051
Database links: Entrez Gene: 2051 Human Entrez Gene: 13848 Mouse Entrez Gene: 312275 Rat Omim: 602757 Human SwissProt: O15197 Human SwissProt: O08644 Mouse SwissProt: P0C0K7 Rat Unigene: 380089 Human Unigene: 271976 Mouse Unigene: 125930 Rat Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长因子和激素（ Growth Factor and Hormones）
有学者认为：EPHB6受体型*蛋白激酶与多种肿瘤的发生和转移负相关，EPHB6作为一种重要的生物学标记，还有许多未知的蛋白功能。
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