| 磷脂酸磷酸酶HTPAP抗体是我司为您提供的高品质抗体，公司生产的每一个抗体都经过严格检测和稳定性测试，保证了结果的准确性、敏感性、特异性。公司产品质量有保证，*，为广大客户提供完善的售前、售中、售后服务，公司生产的产品也已获得广大客户的信赖。南京森贝伽生物科技有限公司为服务更多科研工作者的需要，公司现经营抗体、ELISA试剂盒、标准品、染色液、染色试剂盒、培养基等多种科研产品，如有需要可与我司销售人员。
英文名称 DPPL1
中文名称 磷脂酸磷酸酶HTPAP抗体
别 名 diacylglycerol pyrophosphate like 1; DPPL1; EC=3.1.3.4; HTPAP; Phosphatidate phosphatase PPAPDC1B; Phosphatidic acid phosphatase type 2 domain-containing protein 1B; PPAPDC1B; PPC1B_HUMAN.
说 明 书 0.2ml
研究领域 肿瘤 信号转导 激酶和磷酸酶
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DPPL1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
磷脂酸磷酸酶HTPAP抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
磷脂酸磷酸酶HTPAP抗体产品介绍 background:
DPPL1 and is a 223 amino acid protein that is localized to the cellular membrane. HTPAP is a multi-pass membrane protein which is thought to possess six transmembrane spanning domains and is expressed as two isoforms. HTPAP is a member of the PAP related phosphoesterase family and the gene encoding HTPAP is highly conserved among many species. HTPAP functions as a PAP for lipid phosphate substrates, including PA (phosphatidate), LPA (lysophatidate) and DGPP (diacylglycerol pyrophosphate), but preferentially targets DGPP. Breast cancer tumors, specifically those in which ER (estrogen receptor) is present in high amounts, exhibit upregulation of the gene which encodes HTPAP and HTPAP is thought to increase ER activity. Due to the overexpression of HTPAP in ductal breast carcinomas and the observation that, in cases of lower HTPAP expression, tumors grew slower, HTPAP is thought to be an oncogene. In contrast, the gene encoding HTPAP is downregulated in HCC (hepatocellular carcinoma) and is thought to inhibit lung metastasis.
Function:
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.
Subcellular Location:
Membrane; Multi-pass membrane protein
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the PA-phosphatase related phosphoesterase family.
Database links: Entrez Gene: 84513 Human Entrez Gene: 71910 Mouse Entrez Gene: 680466 Rat Omim: 610626 Human SwissProt: Q8NEB5 Human SwissProt: Q3UMZ3 Mouse Unigene: 567619 Human Unigene: 385055 Mouse Unigene: 199008 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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