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背景资料
Carcinoembryonic antigen （CEA） is a glycoprotein present in fetal digestive-tract tissues； it’s involved in cell adhesion. The production of CEA stops before birth. CEA is called tumor marker since its elevated levels are found in the serum from individuals with colorectal， gastric， pancreatic， lung and breast carcinomas and in heavy smokers.
There are also benign conditions that elevate CEA levels such as smoking， infection， inflammatory bowel disease， pancreatitis， cirrhosis of the liver， and some benign tumors （in the equivalent organs which have cancers with elevated CEA）. Typically， higher levels of CEA are found in men， smokers， and older individuals.
The presence of CEA assists in screening， in evaluating recurrent or disseminated disease， and in determining the success of surgical removal of malignant tumors.
CEA levels can be used as indicators of treatment success. The normal values range from 0.0 to 2.5 ng/ml of serum （from blood）， in non-smokers， a greater amount than that may be suggestive of cancer. Levels above 20 ng/ml before treatment are associated with cancer which has already metastasized. Benign conditions do not usually cause a CEA increase over 10 ng/ml.
The high levels of CEA should return to normal after successful therapy， however if during follow up there’s an elevation in CEA levels it indicates a recurrence of tumor.
Carcinoembryonic antigen family belongs to the immunoglobulin superfamily； it consists of 29 genes， 18 of which are normally expressed.
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来源宿主
杆状病毒-昆虫细胞中重组表达
溶解建议
Sterile Filtered colourless solution. The sterile protein solution contains 10mM NaH2PO4， pH 7 and 150mM NaCl.
保存建议
CEA should be stored at 2-8℃. Please prevent freeze-thaw cycles.
其他
ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
