背景资料
The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis.{26699} MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 µM) without blocking VEGFC-mediated stimulation of VEGFR2.{27479} It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.{27480} By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA.{27477} It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo.{27480} MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.{27478,27476}
产品描述
A selective antagonist of the activation of VEGFR-3 by VEGF-C (IC50 = 1 µM); does not inhibit ligand-induced autophosphorylation of VEGFR-2, EGFR, IGF-1R, or PDGFRβ; reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo
保存建议
建议您在收到开曼生物品牌的MAZ51 (1 mg)产品后置于-20度保存，产品有效期为730天.
其他
开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供的开曼生物产品以及客户订制化服务.
