* 水合物 基本信息:
Cas号 | 分子式 | 分子量 | 别名 |
133073-73-1 59-05-2 | C20H22N8O5.2H2O | 454.44 | * 水合物 ;L-氨甲喋呤 水合物 |
说明介绍:
性状 易溶于稀碱、酸或碱金属的碳酸盐溶液,微溶于*,几乎不溶于水、乙醇、氯仿、.
质量标准
99%:
外观Appearance 黄色至橙色粉末
核磁Proton NMR spectrum Conforms
纯度Purity ≥99.0% (HPLC,面积归一法)
比旋光度Specific rotation [a]20/D +19.0 ~ +24.0 °(C=0.1,1N NaOH)
硫酸盐灰分sulfated ash ≤0.1%
水分Water
品级Grade USP级
(EP, USP testing specifications)
鉴别试验Identity Pass by UV (In Acid and Base)
鉴别试验Identity Pass by IR
比旋度Specific Rotation (anhydrous) 19 - 24 °
水分Water (by Karl Fischer) ≤12.0 %
灼烧残渣Residue on ignition (Ash) ≤0.1 %
重金属Heavy Metal ≤50 ppm
相关化合物Related Compounds Pass
相关物质Related Substances Pass
(R)-*(R)- Methotrexate ≤3.0 %
含量Assay(Anhydrous basis) 98.0 - 102.0 %
残留溶剂Residual Solvents Meets Requirements
贮存 储存温度 −20°C
用途 *拮抗剂,二羟基*还原酶(dihydrofolate reductase)抑制剂。
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