背景资料
20-HETE is a major biologically active cytochrome P450 （CYP450） metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM， selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9， CYP2D6， and CYP3A4， enzymes important in drug metabolism， significantly less effectively with IC50s in the uM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids （EETs） formation are 2.3 and 2.8 uM， respectively.
产品描述
20-HETE is a major biologically active CYP450 metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation.{12466，12470，12468，12467，9023} HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM， selectively inhibiting CYP4A and 4F isoforms.{8946，12469} HET0016 inhibits CYP2C9， CYP2D6， and CYP3A4， enzymes important in drug metabolism， significantly less effectively with IC50 values in the uM range. The IC50 values for inhibition of COX and epoxyeicosatrienoic acids （EETs） formation are 2.3 and 2.8 uM， respectively.{8946}
保存建议
建议您在收到开曼生物品牌的HET0016 （10 mg）产品后置于-20度保存，产品有效期为730天.
其他
开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供面的开曼生物产品以及客户订制化服务.
