白介素1受体2抗体是我司为您提供的高品质抗体,公司生产的每一个抗体都经过严格检测和稳定性测试,保证了结果的准确性、敏感性、特异性。公司产品质量有保证,*,为广大客户提供完善的售前、售中、售后服务,公司生产的产品也已获得广大客户的信赖。南京森贝伽生物科技有限公司为服务更多科研工作者的需要,公司现经营抗体、ELISA试剂盒、标准品、染色液、染色试剂盒、培养基等多种科研产品,如有需要可与我司销售人员。 英文名称 IL-1R2 中文名称 白介素1受体2抗体 别 名 IL1 Receptor II; IL-1R II; IL1 Receptor 2; interleukin-1 receptor type 2 precursor; IL1R2; CD121b; IL1RB; CD121; CD121 antigen-like family member B; CD121b; CD121B Antigen; CDW121B; IL-1R-2; IL-1R-beta; IL-1R2; IL-1RT-2; IL-1RT2; IL1R Beta; Il1r-2; IL1R2; IL1RB; Interleukin 1 receptor, beta, type II; Interleukin 1 receptor, type II; Interleukin-1 receptor beta; Interleukin-1 receptor type 2; MGC137383; MGC47725; p68; IL1 Receptor II; IL1R2_HUMAN. 说 明 书 0.1ml 0.2ml 研究领域 免疫学 干细胞 淋巴细胞 b-淋巴细胞 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Dog, 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 44kDa 性 状 Lyophilized or Liquid 浓 度 1mg/1ml 免 疫 原 KLH conjugated synthetic peptide derived from human IL-1R II 亚 型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed PubMed 产品介绍 background: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4(IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq].
Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Subcellular Location: Isoform Short: Secreted. Isoform Long: Cell membrane; Single-pass type I membrane protein.
Post-translational modifications: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.
Similarity: Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Gene ID: 7850
Database links: Entrez Gene: 7850 Human Omim: 147811 Human SwissProt: P27930 Human Unigene: 25333 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IL-1RⅡ属于新的信号受体家族Toll信号转导通路蛋白,IL-1RⅡ在免疫和炎症反应的研究中占重要地位,是在很多感染 、炎症性致病机制中起决定性作用的细胞因子,几乎可作用于全身各种细胞,IL-1 与IL-1RⅡ的结合可导致大量与免疫反应和炎症相关基因的表达 ,包括细胞因子、细胞因子受体、急性期反应物、生长因子、胞外基质、粘附分子等。IL-1RⅡ/NF-κB信号通路是机体免疫反应中十分重要的组成部分。
|