艾美捷1,2,3-三棕榈酰甘油参数说明

1,2,3-三棕榈酰甘油是在sn-1、sn-2、sn-3和sn-4处含有棕榈酸的三酰基甘油，它抑制葡萄糖刺激的胰岛素分泌，以浓度依赖的方式降低INS1细胞的活力。在链脲佐菌素诱导的糖尿病大鼠模型中，1,2,3-三棕榈酰甘油的心肌水平升高了5倍以上含有依-托-泊-苷的纳米颗粒的基质。含有1,2,3-三棕榈酰甘油的配方已被用作化妆品的增稠剂和皮肤调理剂。

艾美捷1,2,3-三棕榈酰甘油基本参数：

正式名称：1,1'，1''-（1,2,3-丙三醇）十六烷酸酯

CAS编号：555-44-2

同义词：十六酸甘油酯、甘油三棕榈酸酯、甘油三棕榈酸酯、TG（16:0/16:0/16:0）、十六烷酰甘油

纯度：≥85%

配方：结晶固体

溶解性：三-氯-甲-烷：1 mg/ml

存储：-20℃

稳定性：≥4年

艾美捷1,2,3-三棕榈酰甘油相关文献参考：

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2. Moffitt, J.H., Fielding, B.A., Evershed, R., et al. Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. Diabetologia 48(9), 1819-1829 (2005).

3. Han, X., Abendschein, D.R., Kelley, J.G., et al. Diabetes-induced changes in specific lipid molecular species in rat myocardium. Biochem J. 352(Pt. 1), 79-89 (2000).

4. Reddy, L.H., Sharma, R.K., Chuttani, K., et al. Etoposide-incorporated tripalmitin nanoparticles with different surface charge: Formulation, characterization, radiolabeling, and biodistribution studies. AAPS J. 6(3), e23 (2004).

5. Johnson, W., Jr., and Panel, C.I.R.E. Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate. Int. J. Toxicol. 20(Suppl 4), 61-94 (2001).