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广州健仑生物科技有限公司

广州健仑长期供应各种生物原料，主要代理品牌：西班牙Certest。

主要产品包括各种生物单克隆抗原抗体、重组蛋白。

西班牙Certest溶组织内阿米巴重组蛋白

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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加拿大麦吉尔大学乔西·尤西尼-西格尔主持的新研究表明，p66ShcA蛋白富含于经历了上皮间质细胞转移的抗原抗体癌中。在所有抗原抗体癌类型中，p66ShcA表达水平的升高与上皮间质细胞转化基因的表达密切相关。因此，p66ShcA可用作确定各种分子亚型抗原抗体癌预后的*标记。
抗原抗体癌至少有5种亚型，其中每一种都与不同预后结果相关。早期研究表明，亚型具有异质性，因此基于亚型的预后结果不太可靠。研究人员表示，对造成肿瘤细胞异质性和转移基本机制的深入了解，有助于更好地明确疾病的预后发展并提出改善治疗效果的方法。
尽管科学界对脑卒中的认识和治疗有着显著进步，但开发新型和有效的治疗方式以对抗这种疾病仍然是一个主要的临床问题。由脑卒中引起的神经组织损伤是因为血流到大脑的中断造成的，并导致葡萄糖，氧和其他营养成分的缺乏。这会导致梗塞核心快速坏死，并形成缺血半影。这种半影可在亚急性期接受干预治疗。在众多的神经变性途径中，氧化应激已被证明可加剧中枢神经系统中次级细胞死亡。
DJ-1是一种多功能氧化还原敏感蛋白，与氧化应激的细胞死亡级联相关。DJ-1提供的神经保护形式可通过多种途径防止细胞死亡，zui重要的是通过降低线粒体氧化应激和PD聚集蛋白α-突触核蛋白分子陪伴(作用)，以及刺激抗凋亡和抗氧化基因的表达，促进促生存Akt通路从而阻止细胞凋亡信号调节激酶(ASK1)途径，并正调节雄激素受体依赖性转录。在细胞质和细胞核中常见的是，DJ-1可被分泌到病理状态下的血清中，还可以通过有丝分裂原刺激转位到各种哺乳动物细胞的线粒体中，特别令人感兴趣的是，氧化应激。
来自美国南佛罗里达大学医学院Cesar V. Borlongan教授所在团队讨论了其zui近发现的测试，DJ-1不仅可以作为氧化应激的细胞内保护的一种形式，也利用它从旁分泌和/或自分泌线索以完成相邻神经细胞之间的细胞外信号传导从而达到神经保护作用。相关研究内容发表在2014年8月第15期《中国神经再生研究(英文版)》杂志上。
发表于2014年9月16日的《eLife》的新研究中，纽约大学朗格尼医学中心和其他地方的科学家*报告了，一种叫做翻译延伸因子eEF1A1的蛋白掌管了热休克反应的整个过程。通过这样做，eEF1A1支持细胞内的总蛋白的动态平衡，确保其在各种内部和外部的压力条件下正常运转。研究人员表明，这项发现有可能揭示一个有前途的、新的用于神经退行性疾病和癌症的药物靶标。

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【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

New research led by Josie Ussini-Siegel of McGill University in Canada shows that the p66ShcA protein is enriched in antigen-antibody cancers that have undergone epithelial mesenchymal cell metastasis. In all antigen-antibody cancer types, the increased expression of p66ShcA is closely related to the expression of epithelial-derived stromal cells. Therefore, p66ShcA can be used as a first choice marker for determining the prognosis of various molecular subtype antigens.
Antigen Antibody The cancer has at least 5 subtypes, each of which is associated with a different outcome. Early studies have shown that subtypes are heterogeneous, so prognosis based on subtypes is less reliable. The researchers said that an in-depth understanding of the underlying mechanisms responsible for tumor cell heterogeneity and metastasis can help to better define the prognosis of the disease and suggest ways to improve the outcome.
Despite significant advances in the understanding and treatment of stroke in the scientific community, developing new and effective treatments to combat the disease remains a major clinical problem. Nerve tissue damage caused by stroke is caused by a breakdown of blood flow to the brain and results in a lack of glucose, oxygen and other nutrients. This can lead to rapid necrosis of the infarct core and the formation of ischemic penumbra. This penumbra can be sub-acute intervention in the treatment. Among numerous neurodegeneration pathways, oxidative stress has been shown to exacerbate secondary cell death in the central nervous system.
DJ-1 is a multifunctional redox-sensitive protein that is associated with a cascade of oxidative stress. The neuroprotective forms provided by DJ-1 can prevent cell death through a variety of pathways, most importantly by reducing the mitochondrial oxidative stress and the complication of PD-aggregate alpha-synuclein molecules, as well as stimulating anti-apoptotic and anti- Oxidative gene expression promotes the pro-survival Akt pathway thus blocking the apoptotic signal-regulated kinase (ASK1) pathway and upregulating androgen receptor-dependent transcription. It is common in the cytoplasm and nucleus that DJ-1 can be secreted into the serum under pathological conditions and can also be stimulated to translocate to the mitochondria of various mammalian cells by mitogens. Of particular interest is the oxidation of Stress.
The team from Professor Cesar V. Borlongan, University of South Florida School of Medicine, USA, discussed his recently discovered test that DJ-1 can be used not only as a form of intracellular protection of oxidative stress, but also from paracrine and / or Secretion of clues to complete the extracellular signal transduction between adjacent nerve cells to achieve neuroprotective effect. Relevant research is published in the 15th issue of "Chinese Journal of Nervous Regeneration Research (English Edition)" in August 2014.
In a new study, "eLife," published September 16, 2014, scientists at New York University's Langley Medical Center and elsewhere first reported that a protein called the translation elongation factor eEF1A1 governs the entire course of the heat shock response . By doing so, eEF1A1 supports the homeostasis of total protein in the cell and ensures its normal operation under a variety of internal and external stress conditions. Researchers have shown that the discovery is likely to reveal a promising new drug target for neurodegenerative diseases and cancer.