Anti-Phospho-Btk(Ser180),磷酸化*蛋白激酶BTK抗体科研产品介绍：
Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.
与“Anti-Phospho-Btk(Ser180),磷酸化*蛋白激酶BTK抗体科研”有关的产品：
Anti-CDK5(Cyclin Dependent Kinase 5) 周期素依赖性激酶5抗体
Anti-CDK6 (Cyclin Dependent Kinase 6) 周期素依赖性激酶6抗体
Anti-CDK7/Cyclin H/MAT1 周期素依赖性激酶7抗体
Anti-CDK8(Cyclin Dependent Kinase 8) 周期素依赖性激酶8抗体
Anti-CCNT1/CDK9 (Cyclin Dependent Kinase 9) 周期素依赖性激酶9抗体
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Anti-CEA(mouse monoclonal) 鼠抗人癌胚抗原单克隆抗体（包被）
Anti-CEA(mouse monoclonal) 鼠抗人癌胚抗原单克隆抗体（检测）
Anti-Phospho-Btk(Ser180),磷酸化*蛋白激酶BTK抗体科研产品详情：
产品编号：HRK-3055R
产品规格: 0.1ml/0.2ml
产品别名：BTK (phospho S180); p-BTK (phospho S180); Agammaglobulinaemia tyrosine kinase; AGMX 1; AGMX1; AT; ATK; B cell progenitor kinase; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton’s Tyrosine Kinase; Btk; BTK_HUMAN; IMD 1; IMD1; MGC126261; MGC126262; OTTHUMP00000063593; PSCTK 1; PSCTK1; Tyrosine protein kinase BTK; Tyrosine-protein kinase BTK; XLA
产品价格：询价(电询或客服)
产品用途：科研实验
贮 存： 贮存于-20℃.
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