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博研生物现货提供“Anti-APOE抗体,优质载脂蛋白E抗体"，产品质量保证，提供，有任何质量问题可免费包退包换，咨询！
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【产品名称】：Anti-APOE抗体,优质载脂蛋白E抗体报价
【产品编号】：BYK-0167R
【产品规格】：0.1ml/0.2ml
【产品价格】：询价（电询或客服）
【抗体来源】：Rabbit OR Mouse or Goat
【产品用途】：科研实验，用于ELISA实验、免疫组化实验，WB实验，IF实验等，可，索取产品说明书！
【性 状】： Lyophilized or Liquid
【浓 度】： 1mg/1ml
【亚 型】： IgG
【贮 存】： 贮存于-20℃.
【相关标记】：HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
【产品别名】：Apolipoprotein E precursor; AD2; Alzheimer disease 2; Apo E; ApoE; APOEA; ApolipoproteinE; Apolipoprotein-E; Apoprotein; MGC1571; Apo E2; ApoE2; APOE 2; Apolipoprotein E2; LDLCQ5; LPG; APOE_HUMAN; Apo-E.
【产品介绍】：Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. Defects in ApoE are a cause of hyperlipoproteinemia type III due to increased plasma cholesterol and triglycerides levels which are the consequence of impaired clearance of chylomicron and VLDL remnants.
Summary: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
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