载脂蛋白A1结合蛋白抗体抗体*
『别名』AI BP; AIBP; ApoA I binding protein; Apolipoprotein A I binding protein; MGC119143; MGC119144; MGC119145; YjeF N terminal domain containing protein 1; YJEFN1; NNRE_HUMAN.
『浓度』1mg/1ml
『规格』0.2ml/200μg
『抗体来源』Rabbit
『克隆类型』polyclonal
『交叉反应』Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, Chimpanzee
『产品类型』一抗
『研究领域』心血管 细胞生物
『蛋白分子量』predicted molecular weight: 27kDa
『性状』Lyophilized or Liquid
『免疫原』KLH conjugated synthetic peptide derived from human APOA1BP/AI-BP
『亚型』IgG
『纯化方法』affinity purified by Protein A
『储存液』Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
『产品应用』WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
『保存条件』Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
『产品介绍』Apolipoproteins are protein components of plasma lipoproteins. Apolipoprotein A-I (ApoA1) promotes cholesterol efflux from tissues to the liver for excretion. ApoA1 is the major protein component of high density lipoprotein (HDL) in the plasma. It can function as a cofactor for lecithin cholesterolacyltransferase, which is responsible for the formation of most plasma cholesteryl esters. AI-BP (Apolipoprotein A-I-binding protein), also known as YjeF N-terminal domain-containing protein 1, is a 288 amino acid secreted protein that binds ApoA1, ApoA2 and HDL. Individuals with impaired renal function show an increased rate of AI-BP excretion, indicating that it is normally reabsorbed within the kidney tubules. AI-BP belongs to the YjeF N-terminal domain protein family, which includes proteins that are frequently involved in oogenesis and spermatogenesis. There are two isoforms of AI-BP that are produced as a result of alternative splicing events.
Function : APOA1BP interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein 载脂蛋白A1结合蛋白抗体抗体*of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I.
Subunit : Homodimer (By similarity). Interacts with APOA1 and APOA2.
Subcellular Location : Secreted
Tissue Specificity : Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level).
Post-translational modifications : Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation (By similarity).
Similarity : Belongs to the nnrE/AIBP family.
Contains 1 YjeF N-terminal domain.
Database links : UniProtKB/Swiss-Prot: Q8NCW5.2
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