HBeAg重组乙型肝炎病毒e抗原 返回列表页

产品新闻

背景资料

Hepatitis B virus is the main cause for human liver disease， chronic infection frequently causes liver cancer and cirrhosis. The HBV core gene codes 2 distinct protein products， a 21.5-kDa protein being assembled to form nucleocapsid particles designated HBcAg， which wraps the viral DNA as well as the viral polymerase and RNase H， and a precore protein， designated as HBeAg， which is directly to the endoplasmic reticulum， processed at N- and C-terminally and secreted as non-particulate e-anitgen （HBeAg）. The pre-core protein contains an extra 29 N-terminal amino acids， serving as a signal peptide to direct the nascent polypeptide into secretory pathway. After the secretion， mature HBeAg is deleted at the residue 149 C-terminally and retains 10 precore residues N-terminally. HBcAg and HBeAg are distinctly recognized by antibodies but highly cross-reactive at the T-cell level.
The e antigen is found in the circulation， it is found during the active HBV infection， positive result indicates the risk for contagiousness， and is also used as indicator for the effectiveness of HBV treatment. Positive anti-HBeAg specifies an active stage of acute HBV infection that is in its final stages， the risk for contagiousness is dramatically reduced.

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来源宿主

大肠杆菌中重组表达

溶解建议

提供的重组丙型肝炎病毒e抗原产品为溶液形式.该产品已溶解在含2M 尿素的20mM 磷酸钠缓冲液.

保存建议

Five years frozen. One month in solution at room temperature.

其他

ProSpec 是一家 著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。