IL 29重组人白介素-29 返回列表页

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背景资料

IL-29 is distantly related to type I interferons and the IL-10 family. Expression of IL-29 is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor，beta （IL10RB） and interleukin 28 receptor，alpha. IL-29 exhibits common features with type I IFNs such as antiviral activity，antiproliferative activity and in vivo antitumour activity.
IL-29 acts similarly to IFNs，but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1，IFN-lambda 2 and IFN-lambda3 are closely positioned genes on human chromosome 19.
IL-29 induces ELR（-） CXC chemokine mRNA in human peripheral blood mononuclear cells，in an IFN-gamma-independent manner.
IL-29 is able to generate tolerogenic DCs，an activity that could thwart IFN-beta functions. IL-29 produced in response to viral infection，activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection.
IFN-Lambda 1 antiviral and antiproliferative activity requires Interferon-Lambda 2 receptor tyrosine residues.

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大肠杆菌中重组表达

溶解建议

提供的人白介素-29（IL 29）产品为经0.2um孔径过滤灭菌的白色冻干粉末；该冻干粉末是从含人白介素-29（IL 29）的溶液（不含添加剂）中过滤灭菌并冻干产生的.我们建议加无菌的18MΩ-cm水以配制工作储存液到100ug/ml，后继实验过程中可根据实验要求进一步稀释.

保存建议

人白介素-29（IL 29）在室温可保存3周，或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天；如果想延长保存时间，建议分装（加载体蛋白如0.1% HSA或 BSA）后置于-18℃冻存.请避免反复冻融.

其他

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。  生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。