Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins， thromboxanes， and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient， critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release， metabolism， and re-uptake of free arachidonate are all important aspects of cell signaling and inflammation.
Keystone essential fatty acid that is converted by COX， LO， and epoxygenase enzymes into more than 150 potent metabolites in species ranging from fungi to plants to mammals