Recombinant Human Parathyroid Hormone （1-84） 返回列表页

背景资料

Parathyroid hormone （PTH）， or parathormone， is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calciumin the blood， whereas calcitonin （a hormone produced by the parafollicular cells of the thyroid gland） acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptorin three parts of the body: In the bones- It enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts， which are indirectly stimulated by PTH. Stimulation is indirect since osteoclasts do not have a receptor for PTH； rather， PTH binds to osteoblasts， the cells responsible for creating bone. Binding stimulates osteoblasts to increase their expression of RANKL， which can bind to osteoclast precursors containing RANK， a receptor for RANKL. The binding of RANKL to RANK stimulates these precursors to fuse， forming new osteoclasts which ultimately enhances the resorption of bone.

In the kidney- It enhances active reabsorption of calcium from distal tubules and the thick ascending limb.

In the intestine- It enhances the absorption of calcium in the intestine by increasing the production of vitamin D and upregulating the enzyme responsible for 1-alpha hydroxylationof 25-hydroxy vitamin D， converting vitamin D to its active form （1，25-dihydroxy vitamin D） which effects the actual absorption of calcium （as Ca2+ ions） by the intestine via calbindin.

Recombinant Human full length PTH 1-84 has potential as an anti-osteoporotic agent， due to its properties as a bone formation stimulant， it increases bone turnover， stimulating osteoblasts and reducing both vertebral and non vertebral fractures.

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来源宿主

大肠杆菌中重组表达

溶解建议

提供的重组人甲状旁腺素（1-84）产品为白色无菌冻干粉末.推荐使用无菌的18MΩ的超纯水来溶解，浓度不低于100ug/ml，便于后续稀释.

保存建议

Lyophilized Parathyrin although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution PTH should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.

其他

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