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当前位置:上海泛柯实业有限公司>>抗体>>一抗>>FITC标记的*蛋白激酶受体A8抗体

FITC标记的*蛋白激酶受体A8抗体

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更新时间:2018-05-24 18:22:33浏览次数:695次

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所在地区:上海上海

联系人:马经理 (销售专员)

产品简介

FITC标记的*蛋白激酶受体A8抗体产品介绍:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

详细介绍

英文名称Anti-EphA8/FITC
中文名称FITC标记的*蛋白激酶受体A8抗体
别    名2.7.1.112; EEK; EK3; EPH and ELK related kinase; EPH like kinase 3; Eph receptor A8; EPH- and ELK-related kinase; EPH-like kinase 3; EphA8; EPHA8_HUMAN; Ephrin Type A Receptor 8 Precursor; Ephrin type-A receptor 8; HEK3; KIAA1459; Tyrosine-protein kinase receptor EEK; Tyrosylprotein Kinase.
说 明 书100ul  
研究领域心血管  细胞生物  神经生物学  信号转导  激酶和磷酸酶  细胞类型标志物  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, 
产品应用IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量108kDa
细胞定位细胞膜 
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human EphA8/Eph receptor A8
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]

Function:
Receptor for members of the ephrin-A family.

Subunit:
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. May also form heterodimers with other ephrin receptors (By similarity). Interacts with FYN; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PIK3CG; regulates integrin-mediated cell adhesion to substrate. Interacts with TIAM1; regulates clathrin-mediated endocytosis of EPHA8. Interacts with ANKS1A and ANKS1B; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination.

Subcellular Location:
Membrane.

Post-translational modifications:
Phosphorylation on Tyr-616 is critical for association with FYN.
Phosphorylation on Tyr-839 modulates tyrosine kinase activity.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain. 


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