| 英文名称 | Anti-ASTE1/FITC |
| 中文名称 | FITC标记的ASTE1蛋白抗体 |
| 别 名 | ASTE1; ASTE1_HUMAN; Asteroid homolog 1 (Drosophila); HT001; MGC129980; OTTHUMP00000216085; Protein asteroid homolog 1. |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 77kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ASTE1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background:
ASTE1 is a 679 amino acid protein that belongs to the asteroid family. Encoded by a gene that maps to human chromosome 3q22.1, ASTE1 is conserved in chimpanzee, cow, mouse, rat and zebrafish. ASTE1 is strongly linked to tumor-infiltrating lymphocytes in colorectal cancers with microsalite instability, with lymphocyte density correlating to frameshift mutation presence and frequency within ASTE1. Severe colorectal dysplasia with microsalite instability also exhibits frameshift mutations within ASTE1, suggesting that ASTE1 mutations occur early during microsalite instability-induced colorectal carcinogenesis. ASTE1 frameshift mutations may generate a premature stop codon in the last exon that does not result in nonsense-mediated mRNA decay, thereby allowing mutated ASTE1 proteins to be highly expressed and exceptionally immunogenic. Frameshift mutations in ASTE1 are also linked to the manifestation of neoantigens, potentially recognized by T cells, possibly resulting in specific immune responses against specific neoantigens.
Function:
Possible role in EGF receptor signaling (By similarity).
Similarity:
Belongs to the asteroid family. |
