|参 考 价||面议|
FITC标记的褐黑素相关蛋白ART抗体产品介绍：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|别 名||Agouti Related Protein Homolog; agouti signaling protein; agouti switch protein; Agouti-related protein; Agrp; AGRP_HUMAN; AGRT; ART; ASIP2.|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 神经生物学 信号转导|
|产品应用||ICC=1:50-200 IF=1:50-200 |
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||12kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human AGRP (31-80aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Interacts with melanocortin receptors MC3R, MC4R and MC5R.
Secreted. Golgi apparatus lumen.
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
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