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髓过氧化物酶抗中性粒细胞胞质IgG抗体

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更新时间:2018-05-09 17:29:18浏览次数:421次

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商铺产品:9811条

所在地区:上海上海

联系人:马经理 (销售专员)

产品简介

髓过氧化物酶抗中性粒细胞胞质IgG抗体产品介绍:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

详细介绍

英文名称Myeloperoxidase
中文名称髓过氧化物酶抗中性粒细胞胞质IgG抗体
别    名Myeloperoxidase; MPO; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.
说 明 书0.1ml  0.2ml  
研究领域肿瘤  细胞生物  免疫学  激酶和磷酸酶  淋巴细胞  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, 
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量77kDa
细胞定位细胞浆 
性    状Lyophilized or Liquid
浓    度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Myeloperoxidase
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].

Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Subunit:
Tetramer of two light chains and two heavy chains.

Subcellular Location:
Lysosome.


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