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兔抗小鼠IgA抗体

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更新时间:2018-05-10 08:50:55浏览次数:352次

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产品简介

兔抗小鼠IgA抗体储 存 液:0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide。

详细介绍

英文名称Mouse IgA
中文名称兔抗小鼠IgA抗体
别    名A2m marker; FLJ14473; FLJ35065; FLJ35500; FLJ36402; FLJ39698; FLJ40001; FLJ41548; FLJ41552; FLJ41789; FLJ43248; FLJ43594; FLJ44293; FLJ46028; FLJ46621; FLJ46724; FLJ46811; FLJ46824; Ig alpha 1 chain C region; Ig alpha 2 chain C region; IgA1; Igh2; IGHA 1; IGHA 2; IGHA1; IGHA2; Immunoglobulin alpha 1; Immunoglobulin Am1; Immunoglobulin Am2; Immunoglobulin heavy chain 2 (serum IgA); Immunoglobulin heavy constant alpha 1; Immunoglobulin heavy constant alpha 2; MGC102857.
说 明 书0.2ml  
研究领域细胞生物  免疫学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, 
产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
细胞定位分泌型蛋白 
性    状Lyophilized or Liquid
浓    度1mg/1ml
免 疫 原Mouse IgA protein purified
亚    型IgG
纯化方法affinity purified by Protein A from plasma
储 存 液0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA. OR: The secretory component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.

Subcellular Location:
Secreted

Gene ID:
3494

Database links:

Entrez Gene: 3494 Human

Entrez Gene: 5284 Human

Omim: 146900 Human

Omim: 147000 Human

Omim: 173880 Human

SwissProt: P01876 Human

SwissProt: P01877 Human


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