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阅读：389发布时间：2014-5-5
Rabbit Anti-SLUG抗体现货，SLUG抗体wb ihc吃操作说明
Catalog Number : Quantity size : 0.1ml (dilute with pH 7.4
0.01 M PBS or antibody diluent )
Background: The SNAIL family of developmental regulatory proteins is a group of
widely conserved zinc-finger proteins that regulate transcription and include the
mammalian proteins SLUG, SNAI 1 (the human homolog of Drosophila SNAIL) and
Smuc. SNAI 1 and SLUG are expressed in placenta and in adult heart, liver, and
skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain
three classic zinc fingers and one atypical zinc finger , while SLUG contains five zinc
finger regions and a transcriptional repression domain at the amino-terminus, which
enables SLUG to act as a negative regulator of gene expression. SLUG is implicated
in the generation and migration of neural crest cells in human embryos and also
contributes to limb bud development. In addition, SLUG also constitutes a cellular
anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B
cells deprived of IL-3. The SNAIL-related gene from murine skeletal muscle cells,
Smuc, is highly expressed in skeletal muscle and thymus and can, likewise, repress
gene transcription. Smuc preferentially associates with CAGGTG and CACCTG
E-box motifs (CANNTG) on DNA and involves the five putative DNA-binding zinc
finger domains at the C-terminal region of Smuc.
pecificity :
– Anti- SLUG is a rabbit polyclonal antibody unconjugated
– specific for SLUG of human, mouse and rat
– use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 30kDa
Application :
– Western blotting 1:100-500
– Immunohistochemistry 1:100-500
– ELISA 1:500-1000
– Optimal working dilutions must be determined by the end user.
Storage: Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. The
lyophilized antibody is stable at room temperature for at least one month and for
greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M
PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for
use in human, therapeutic or diagnostic applications.
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