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华瑞科研网-ELISA试剂盒
“Anti-phospho-CDKN2A(Ser8),磷酸化抑癌基因p16抗体科研“我公司拥有*的细胞服务技术,*的仪器设备和专业的ELISA检测试剂盒、生物索标记、荧光索标记、酶标记等,广泛用于多种分析研究与技术测定。咨询,我们将竭诚为你服务!
Anti-phospho-CDKN2A(Ser8),磷酸化抑癌基因p16抗体科研产品介绍:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
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Anti-phospho-CDKN2A(Ser8),磷酸化抑癌基因p16抗体科研产品详情:
产品编号:HRK-5255R
产品规格: 0.1ml/0.2ml
产品别名:p-CDKN2A/p16-INK4a(Ser8); p-p16-INK4a(Ser8); cyclin-dependent kinase inhibitor 2A;CDK4I; p16-INK4; p16-INK4a; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A, isoform 1; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cell cycle inhibitor; cyclin-dependent kinase inhibitor 2a p16Ink4a; cell cycle regulator; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 2; Cdkn2a; Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF; CD2A1_HUMAN
产品价格:询价(电询或客服)
产品用途:科研实验
贮 存: 贮存于-20℃.
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