ADP核糖基化因子5抗体品牌
『别名』ADP ribosylation factor 5; ADP-ribosylation factor 5; ARF 5; Arf5; ARF5_HUMAN.
『浓度』1mg/1ml
『规格』0.2ml/200μg
『抗体来源』Rabbit
『克隆类型』polyclonal
『交叉反应』Human, Mouse, Rat, Chicken, Cow, Rabbit
『产品类型』一抗
『研究领域』细胞生物 信号转导 转运蛋白
『蛋白分子量』predicted molecular weight: 20kDa
『性状』Lyophilized or Liquid
『免疫原』KLH conjugated synthetic peptide derived from human ARF5
『亚型』IgG
『纯化方法』affinity purified by Protein A
『储存液』Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
『产品应用』WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
『保存条件』Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
『产品介绍』The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF-dependent regulatory mechanisms include the coordination of spectrin interactions with golgi membranes and the association of actin to the golgi via rho family-dependent G-protein localization (Rac, CDC42) and WASP/Arp2/3 complexes. Additionally, ARFs play a central role in maintenance of organelle integrity, assembly of coat proteins, and activation of phospho-lipase D. The ARF proteins are categorized as class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6); members of each class share a common gene organization.
Function : GTP-binding protein that functions as an ADP核糖基化因子5抗体品牌allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Subunit : Binds ASAP2. Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4.
Subcellular Location : Golgi apparatus. Cytoplasm > perinuclear region.
Similarity : Belongs to the small GTPase superfamily. Arf family.
Database links : UniProtKB/Swiss-Prot: P84085.2
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