近来研究发现,STC-1在人类肿瘤的发生发展中也有着重要的作用.ELISA试剂盒监测STC-1可作为一种稳定因子促进新生血管的成熟而发挥促肿瘤增殖生长，还可通过自分泌途经与肿瘤细胞表面的趋化因子和整合素相互作用,激活一系列细胞内信号,引起多种蛋白分泌,从而溶解细胞外基质屏障,使肿瘤发生侵润和转移。
英文名称 Anti-Stanniocalcin 1
中文名称 斯钙素抗体
别 名 Stanniocalcin; STC; STC1.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型 一抗
研究领域 肿瘤 免疫学 神经生物学 信号转导 生长因子和激素 海洋生物
蛋白分子量 predicted molecular weight: 28kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Stanniocalcin 1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
ELISA试剂盒监测斯钙素抗体产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq].
ELISA试剂盒监测STC1蛋白实在哺乳动物中发现的糖蛋白激素,参与机体的多种生理功能,不但可以通过肾脏和肠道系统来调节钙和磷酸盐的稳态,而且在促进脑神经元的终末分化、防止因大脑局部缺血造成脑神经元的损害、以及骨和肌肉的发育等方面也有重要作用.
