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可替宁试剂 可替宁检测试剂盒
广州健仑生物科技有限公司
本司长期供应尼古丁(可替宁)检测试剂盒,其主要品牌包括美国NovaBios、广州健仑、广州创仑等进口产品,国产产品,试剂盒的实验方法是胶体金方法。
我司还提供其它进口或国产试剂盒:登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。
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【包装规格】
1人份/袋,40人份/盒
【预期用途】
尼古丁(Nicotine)是烟草中的主要生物碱,是导致吸烟成瘾的物质动因,也是评价人体摄入烟草烟雾的常用指标。但因为尼古丁半衰期短,无法作为标志物检测,其代谢物可替宁因为半衰期长作为吸烟和戒烟的标志物。
本品采用竞争抑制法和胶体金免疫层析技术,用于快速定性检测人体唾液中的可替宁,适用于评价烟草烟雾摄入的初步筛查。
【主要组成成份】
【检验方法】
可替宁试剂 可替宁检测试剂盒
后者是CB1受体中由疏水氨基酸残基所形成的一种配体结合口袋。其形状与配体的互补性越大,则受体与配体的亲和力也就越大。 此次,刘志杰课题组“解析”了CB1与拮抗剂AM6538复合物的高分辨率精细结构,*揭示了拮抗剂小分子是如何与受体相互作用的。“它的结合口袋以及相互作用的关键氨基酸,对今后设计高特异性的抑制剂类药物提供了非常重要的结构及理论基础,也为分析不同类型的分子配体与受体的作用模式提供了更精确的三维结构模型。”刘志杰介绍道。 更重要的是,该研究团队发现之前发表的关于CB1的三维预测模型大部分都不是很准确,这就导致设计出来的药物小分子的特异性不高,会同时作用于与CB1同源性较高的其他受体而产生副作用。 “作为治疗抑郁症和戒细菌的潜在靶点,CB1对于抗焦虑的疗效也具有潜力。它主要分布于中间神经元,从而发挥行为抑制的优势。”李扬解释说,“比如抑郁症的发生,一方面是情绪中枢功能亢进,另一方面就是高级认知功能低下和行为抑制功能失控。CB1主要作用负面情绪调节,增强判断力。” 相关药物研究将有所突破 “因为结构不明,所以一直以来在抗抑郁症等领域对于CB1的关注不够。当然,抑郁症的发病机制比较复杂,治疗途径也包括多种通路。目前来说,上处于临床一期、二期、三期在研的抗抑郁药有几十种,针对人体内二十多种靶点,其中CB1则属于潜在靶点之一。”李扬表示,“刘志杰教授的贡献会让更多的人将注意力转移到CB1。” 刘志杰表示,这项研究在对药物依赖治疗的研究中就将起到一定作用。“以前的研究报道,内源性细菌系统在尼古丁成瘾神经机制中具有重要的作用,CB1的拮抗剂可以减少对尼古丁的渴求行为。我们的晶体结构揭示了拮抗剂小分子与CB1的复杂疏水结合口袋,AM6538非共价的紧密结合模式使其具备了成为长效缓释药物分子的巨大潜力,这一特性也是治疗成瘾障碍药物的基本要求。”
想了解更多的韩国SD产品及服务请扫描下方二维码:我司还提供其它进口或国产试剂盒:登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。
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【公司名称】 广州健仑生物科技有限公司
【】 杨永汉
【】
【腾讯 】
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化宣传】
The latter is a ligand-binding pocket formed by hydrophobic amino acid residues in the CB1 receptor. The greater the complementarity between the shape and the ligand, the greater the affinity of the ligand to the ligand. This time, Liu Zhijie's group "resolved" the high-resolution fine structure of CB1 and the antagonist AM6538 complex, revealing for the first time how antagonistic small molecules interact with the receptor. "Its binding pocket and key amino acids interacting provide a very important structural and theoretical basis for the design of highly specific inhibitor drugs in the future, as well as providing insight into the mode of action of different types of ligands and receptors More accurate three-dimensional structural model. "Liu Zhijie introduction road. More importantly, the team found that most of the previously published three-dimensional predictive models for CB1 were not very accurate, leading to low specificity of the designed drug small molecule and simultaneous effects on CB1 homology High side effects of other receptors. "CB1 also has potential for anxiolytic efficacy as a potential target for the treatment of depression and bacteriocidosis, and it is mainly distributed in the interneurons, thereby exerting the advantage of behavioral inhibition." Li Yang explained that "such as the occurrence of depression , On the one hand is the emotional center hyperthyroidism, on the other hand is the high cognitive dysfunction and behavioral inhibition function out of control .CB1 main negative emotional regulation, enhance the ability to judge. "Relevant drug research will be a breakthrough" because the structure is unknown, so has been Since the depression in areas such as CB1 is not enough attention.Of course, the pathogenesis of depression is more complex, the treatment also includes a variety of pathways.At present, the international phase one, two, three in the research There are dozens of antidepressants targeted at more than 20 kinds of targets in the human body, of which CB1 is one of the potential targets. "Li Yang said," Professor Liu Zhijie's contribution will allow more people to divert attention to CB1 "Liu Zhijie said the study will play a role in the study of drug dependence. Previous studies have reported that endogenous bacterial systems play an important role in the nicotine addiction neural mechanism, and CB1 antagonists can reduce the thirst for nicotine.Our crystal structure reveals a complex hydrophobic interaction between small antagonist molecules and CB1 In combination with the pockets, AM6538's non-covalent, tightly-coupled mode of delivery gives it the potential to become a long-acting, sustained-release drug molecule that is also essential for the treatment of addictive disorders. "
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