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Panbio登革热IgG/IgM抗体检测试剂（胶体金法）

广州健仑生物科技有限公司

本公司为大家供应各种进口品牌登革热检测试剂盒，包括澳洲Panbio、美国NovaBios、美国CORTEZ等美国CDC品牌。主要包括胶体金、酶免、PCR等方法学。欢迎咨询

Panbio登革热IgG/IgM抗体检测试剂（胶体金法）

非洲工作用登革热试纸

热带国家旅游用登革热检测试纸

登革热IgM抗体、登革热IgG抗体、登革热NS1抗原、登革热早期检测试剂盒

登革热核酸检测试剂盒

Panbio公司简介:
1、1988年成立，2001年在澳大利亚证券交易所上市。
2、Panbio系关于虫媒感染性疾病及热带感染性疾病的专业供货商。
3、产品面向虫媒感染性疾病的检测，在国内疾控系统具有*的认知和认可度。
4、2010年销售800万检测试剂，为30多种疾病提供诊断。

Panbio登革热介绍：

1、登革热快速检测试剂(Dengue Duo Cassette R-DEN03D)
用于定性的快速检测人群血清、血浆或全血中登革病毒的IgM及IgG抗体。可在15分钟内检测结果。

2、登革IgM捕捉ELISA(Dengue IgM Capture ELISA E-DEN01M)
用于定性的检测人群血清中登革病毒的IgM抗体，用于临床实验室对具有持续发烧的登革热症状的病人的辅助诊断。

3、登革IgG捕捉ELISA(Dengo IgG Capture ELISA E-DEN02G)
用于定性检测血清中登革病毒(血清型1、2、3及4型)的IgG抗体。用于临床实验室对继发登革热感染的辅助诊断。

4、登革早期ELISA(Dengue Early ELISA E-DEN01P)
用于定性检测血清中登革病毒的NS1抗原(血清型1、2、3及4型)。用于临床实验室对有持续发烧的登革热症状病人的辅助性诊断。

5、登革IgG间接ELISA(Dengue IgG Indirect ELISA E-DEN01G)
用于定性检测血清中登革病毒(血清型1、2、3及4型)的IgG抗体，用于临床实验室对具有持续发烧的登革感染症状或接触史的患者的辅助性诊断。

6、登革IgM & IgG联检ELISA(Dengue Duo IgM & IgG Capture ELISA E-DEN01D)
用于定性检测血清中登革病毒的IgM和IgG抗体。可以区分原发感染与继发感染。

Dengue产品介绍

Panbio

流行情况/登革热病 panbio登革热
人类记载的*次登革热病流行发生在1648年的墨西哥的尤卡坦半岛。此前在加勒比海地区已有该病存在。
17至19世纪，该病通过交通运输、人员流动传人北美和欧洲后，成为美洲、非洲及欧洲部分地区zui严重的传染病之一，曾造成人群大量死亡及部分社会活动瘫痪。
1741年，英国27000名士兵攻打哥伦比亚，因20000人感染登革热病而溃不成军；1762年英国殖民军侵略古巴，15000名士兵中8000人死于登革热病；
1793年，美国费城登革热病大流行，全市1/5人口死于登革热病，导致社会*解体。其后疫情沿密西西比河深人到北美中心地带，美国至少有50万人罹患此病；
1800年，西班牙发生登革热病，死亡至少6万人；
1851年，巴西首都里约热内卢因登革热病至少死亡23000人；
巴拿马运河开凿*期工程中曾因本病严重流行而迫使工程停顿；
1826年英国殖民者人侵非洲时发生本病，535名殖民军在两个月中死亡115人；
1940年以前，登革热病在非洲同样是大小流行不断造成人员大量死亡。
1959年，扎尹尔和苏丹相继出现暴发流行。1960～1962年埃塞俄比亚发生严重大流行，100万人口中约10%感染本病，其中死亡3万人。
20世纪60年代以来，非洲和南美洲的登革热病暴发一直未曾中断。每年向世界卫生组织报告的病例数波动在近百例至数千例不等。
1987～1991年间，登革热病在尼日利亚流行，几十万人受到感染。
2012年11月1日，位于苏丹西部的中达尔富尔州和南达尔富尔州有47名公民感染登革热病死亡，苏丹登革热病患者已超过92例。登革热 至2012年11月5日，苏丹达尔富尔地区登革热病疫情，疑似病例达到194例，其中包括67例死亡病例，死亡率为34.5%。登革热
病Panbio登革热理/登革热病 panbio登革热
病原学
病原为登革热病病毒（yellow fever virus），属黄病毒科（family Flaviviridae）的黄病毒属（genus Flavivirus）（过去的虫媒病毒B组）与同属的登革热病毒等有交叉免疫反应。病毒颗粒呈球形，直径37～50nm，外有脂蛋白包膜，包膜表面有刺突。病毒基因组为单股正链RNA，分子量约为3.8×106 ，长约11kb，只含有一个长的开放读码框架，约96%的核苷酸在此框架内。黄病毒基因组分为二个区段：5'端1/4编码该病毒3个结构蛋白，即C蛋白（衣壳蛋白）、M蛋白（膜蛋白）和E蛋白（包膜蛋白）；3'端3/4编码7个非结构蛋白。基因组的5'端和3'端均有一段非编码区。
E蛋白是主要的包膜糖蛋白，含Panbio登革热毒血凝素和中和抗原决定簇，可能是某些宿主细胞表面受体的配体，当它与受体结合，可对细胞产生感染。E蛋白可能是一种膜融合蛋白，可诱导病毒颗粒的包膜与细胞膜融合，促使病毒颗粒进入细胞而引起感染。M蛋白能导致病毒的感染性增加，并形成病毒颗粒的表面结构。非结构蛋白的作用尚不十分清楚，在病毒免疫反应中可能起重要作用。
登革热病病毒有嗜内脏如肝、肾、心等（人和灵长类）和嗜神经（小鼠）的特性。经鸡胚多次传代后可获得作为疫苗的毒力减弱株。易被热、常用消毒剂、Panbio登革热、去氧胆酸钠等迅速灭活，在50%甘油溶液中可存活数月，在冻干情况下可保持活力多年。小鼠和恒河猴是常用的易感实验动物。
发病机理
病毒侵入人体后扩散到局部淋巴结，并在其中复制繁殖，数日后进入血循环形成病毒血症，主要累及肝、脾、肾、淋巴结、骨髓、横纹肌等。以后病毒从血中消失，而在脾、骨髓、淋巴结等处仍可检出。病毒的强毒株常主要侵犯肝脏，并引起严重病变。
病理改变
登革热病的病理变化乃病毒聚集于各器官组织，并在其中复制增殖所引起。肝病变主要见于小叶中间带，肝细胞呈浊肿、点状凝固性坏死及嗜酸性透明变性，形成具相当特征性的康氏小体（Councilman bodies）；严重肝病变可导致深度黄疸、各处出血、低血糖等。Panbio登革热变轻重不一；见于近曲小管，小管上皮浊肿、脱落或坏死，管腔充塞颗粒样碎屑；肾功能减退和尿毒症乃血容量减少、肾小管坏死等所引起。心肌有广泛退行性变和脂肪浸润，偶有灶性出血，病变常累及窦房结和希氏束；临床上可出现心率减慢、心律失常、低血压、心力衰竭等。脑部偶见水肿及灶性出血，系继发于脑组织缺氧和乳酸血症等代谢改变，而非病毒直接侵犯所致。各脏器组织元炎症细胞浸润，此乃本病的特征之一。出血倾向与血小板减少、血小板功能异常和凝血因子减少有关。

Panbio

我司还提供其它进口或国产试剂盒：登革热、疟疾、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

想了解更多的Panbio产品及服务请扫描下方二维码：

【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

references：

Epidemic situation / dengue fever panbio dengue fever
The first recorded dengue fever epidemic in humans occurred in the 1648 Mexican Yucatan Peninsula. The disease had previously existed in the Caribbean.
From the 17th to the 19th century, the disease became one of the most serious infectious diseases in the Americas, Africa and parts of Europe through transportation and personnel transmission to North America and Europe, which caused a large number of deaths and paralysis of some social activities.
In 1741, the United Kingdom 27,000 soldiers attacked Colombia, due to 20,000 people infected with dengue fever and failed; 1762 British colonial army invaded Cuba, 15,000 soldiers in 8000 people died of dengue fever;
In 1793, the United States Philadelphia dengue fever pandemic, the city's 1/5 population died of dengue fever, leading to the community compley disintegrated. Followed by the epidemic along the Mississippi River deep to the North American center, the United States at least 50 million people suffering from the disease;
In 1800, dengue fever occurred in Spain, killing at least 60,000 people;
In 1851, the Brazilian capital Rio de Janeiro died of dengue fever at least 23,000 people;
Panama Canal digging the first phase of the project because of the serious epidemic and forced the project to stop;
1826 British colonial invasion of Africa when the disease, 535 colonial troops died in two months 115;
1940 years ago, dengue fever in Africa is also the size of the popular continue to cause a large number of deaths.
In 1959, Zaire and Sudan have been outbreaks. 1960 ~ 1962 Ethiopia serious pandemic, 1 million people about 10% of the population infected with the disease, of which 30,000 people died.
Since the 1960s, dengue fever outbreaks in Africa and South America have not been interrupted. The number of cases reported annually to the World Health Organization varies from nearly one hundred to several thousand cases.
Between 1987 and 1991, dengue fever was prevalent in Nigeria and hundreds of thousands of people were infected.
On November 1, 2012, 47 people in Darfur and Southern Darfur in western Sudan were infected with dengue fever and more than 92 cases of dengue fever in Sudan. Dengue fever to November 5, 2012, Sudan, Darfur region dengue fever epidemic, suspected cases reached 194 cases, including 67 cases of death, the mortality rate was 34.5%. dengue
Sick Panbio dengue fever / dengue fever panbio dengue fever
Etiology
The genotype Flavivididae (genus Flavivirus), a genus Flaviviridae, has a cross-immune response with the same genus dengue virus. Virus particles were spherical, diameter 37 ~ 50nm, outside the lipoprotein capsule, capsule surface spikes. The viral genome is a single stranded stranded RNA with a molecular weight of about 3.8 x 106 and a length of about 11 kb, containing only a long open reading frame, about 96% of the nucleotides within this framework. The flavivirus genome is divided into two sections: the 5 'end 1/4 encodes the three structural proteins of the virus, namely protein C (capsid protein), M protein (membrane protein) and E protein (envelope protein) Terminal 3/4 encodes 7 nonstructural proteins. The 5 'and 3' ends of the genome have a noncoding region.
E protein is the main envelope glycoprotein, containing Panbio dengue fever hemagglutinin and neutralizing antigenic determinants, which may be ligands of certain host cell surface receptors, when it binds to receptors and can infect cells. E protein may be a membrane fusion protein that can induce the envelope of the viral particles to fuse with the cell membrane, causing the virus particles to enter the cell and cause infection. M protein can cause increased infectivity of the virus and form the surface structure of the virus particles. The role of nonstructural proteins is not yet clear and may play an important role in the viral immune response.
Dengue fever virus has the characteristics of nausea such as liver, kidney, heart (human and primate) and neurotropic (mouse). After repeated passage of chicken embryos can be obtained as a virulence of the vaccine attenuated strain. Easy to be hot, commonly used disinfectants, Panbio dengue fever, sodium deoxycholate and other rapid inactivation, in 50% glycerol solution can survive for several months, in the case of freeze can remain viable for many years. Mice and rhesus are commonly used susceptible experimental animals.
Pathogenesis
After the virus invades the human body after the spread to the local lymph nodes, and in which reproduction and reproduction, a few days later into the blood circulation to form viremia, mainly involving the liver, spleen, kidney, lymph nodes, bone marrow, striated muscle and so on. After the virus disappeared from the blood, and in the spleen, bone marrow, lymph nodes, etc. can still be detected. Virus virulent strains often violate the liver and cause serious lesions.
Pathological changes
The pathological changes of dengue fever are caused by the accumulation of viruses in various organs and tissues. Liver lesions are mainly seen in the middle lobes, the liver cells are turbid, dot-like coagulation necrosis and eosinophilic transparent degeneration, the formation of a very characteristic of the body of the body (Councilman bodies); severe liver disease can lead to deep jaundice, everywhere Bleeding, hypoglycemia and so on. Panbio dengue fever varies severity; seen in the proximal tubule, tubule epithelium swelling, shedding or necrosis, luminal filling of granular debris; renal dysfunction and uremia is caused by reduced blood volume, renal tubular necrosis and so on. Myocardium has a wide range of degenerative changes and fat infiltration, occasional focal bleeding, lesions often involving sinus node and Xi bundle; clinical can be heart rate, arrhythmia, hypotension, heart failure and so on. Brain edema and focal bleeding, the Department of secondary to brain tissue hypoxia and lactic acid and other metabolic changes, rather than a direct violation of the virus. Each organ tissue element inflammatory cell infiltration, which is one of the characteristics of the disease. Hemorrhagic tendency is associated with thrombocytopenia, abnormal plaet function, and reduced coagulation factors.